HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 12017Generated: October 29, 2026
Chlorotrimethylsilane → 3-Trimethylsilyl-L-alanine methyl ester hydrochloride
https://huagongshe.com/reaction/12017
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | HCID 57435232 | HCID 57435232 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Trimethylsilyl-L-alanine methyl ester hydrochloride | HCID 86619132 | — |
Reaction Steps
The compound of Example 6A (300 mg) is dissolved in methanol (3 ml) and cooled to 0° C. Trimethylsilyl chloride (590 mg, 4.7 eq.) is added dropwise in the course of 30 min. and the mixture is warmed to RT overnight. The volatile components are removed on a Rotavapor and subsequently under high vacuum. The target compound (224 mg, 92% of th.) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07727956B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-973258b32ab84a219a5fabe31279058c |
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| Source note | uspto-grants-2010_06 |
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