Tetrahydrofuran → (+/-)-5-Bromo-1,3-dihydrospiro[indene-2,3'-indol]-2'(1'H)-one

HRID 120190Notes

Reaction equation

HRID 120190 reaction equation
[Br:24][c:25]1[cH:26][c:27]([CH2:33][Br:34])[c:28]([CH2:31][Br:32])[cH:29][cH:30]1.[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:16][N:17]([CH3:18])[CH2:19][CH2:20][N:21]([CH3:22])[CH3:23].[Li:11][CH2:12][CH2:13][CH2:14][CH3:15].[NH:1]1[C:2](=[O:10])[CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]21>>[NH:1]1[C:2](=[O:10])[C:3]2([c:4]3[cH:5][cH:6][cH:7][cH:8][c:9]31)[CH2:31][c:28]1[c:27]([cH:26][c:25]([Br:24])[cH:30][cH:29]1)[CH2:33]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 321710OxindoleHCID 124964654-Bromo-1,2-bis(bromomethyl)benzeneHCID 178418339Butyllithium

Product 1

HCID 59166726(+/-)-5-Bromo-1,3-dihydrospiro[indene-2,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-045fb7b3f7094178b0aaf81a7416af82
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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