Toluene → [2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methanol

HRID 1202415Notes

Reaction equation

HRID 1202415 reaction equation
[CH3:25][CH:26]([CH2:27][AlH:28][CH2:29][CH:30]([CH3:31])[CH3:32])[CH3:33].[CH3:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[CH:1]1([c:4]2[n:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[c:12](-[c:18]3[cH:19][cH:20][c:21]([F:24])[cH:22][cH:23]3)[c:13]2[C:14](=[O:15])[O:16][CH3:17])[CH2:2][CH2:3]1>>[CH:1]1([c:4]2[n:5][c:6]3[cH:7][cH:8][cH:9][cH:10][c:11]3[c:12](-[c:18]3[cH:19][cH:20][c:21]([F:24])[cH:22][cH:23]3)[c:13]2[CH2:14][OH:15])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 14487Diisobutylaluminum hydrideHCID 9901664Methyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate

Product 1

HCID 9817555[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methanol

Sources & evidence

ORD record
ord-789779e5774844bbad61e0d31b71f22a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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