Dichloromethane → tert-butyl N-[1-[2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl]pyrrolidin-3-yl]carbamate

HRID 1204034Notes

Reaction equation

HRID 1204034 reaction equation
[CH3:33][CH2:34][N:35]([CH2:36][CH3:37])[CH2:38][CH3:39].[Cl:14][c:15]1[n:16][c:17](-[c:26]2[c:27]([OH:32])[cH:28][cH:29][cH:30][cH:31]2)[n:18][c:19]2[cH:20][c:21]([CH3:25])[cH:22][cH:23][c:24]12.[Cl:40][CH2:41][Cl:42].[NH:1]1[CH2:2][CH:3]([NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[CH2:4][CH2:5]1>>[N:1]1([c:15]2[n:16][c:17](-[c:26]3[c:27]([OH:32])[cH:28][cH:29][cH:30][cH:31]3)[n:18][c:19]3[cH:20][c:21]([CH3:25])[cH:22][cH:23][c:24]23)[CH2:2][CH:3]([NH:6][C:7]([O:8][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:13])[CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 1361050322-(4-Chloro-7-methylquinazolin-2-yl)-phenol

Product 1

HCID 136121483tert-butyl N-[1-[2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl]pyrrolidin-3-yl]carbamate

Sources & evidence

ORD record
ord-d6921cd28eff4c809186fe3a23c19629
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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