Hydrochloric Acid → HCID 178512600, compound

HRID 12042Notes

Reaction equation

HRID 12042 reaction equation
C([O:3][C:4]([CH:6]1[C:11]2[N:12]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:14][C:10]=2[CH2:9][CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+].Cl>CO.O>[NH:15]([C:13]1[S:14][C:10]2[CH2:9][CH2:8][CH2:7][CH:6]([C:4]([OH:5])=[O:3])[C:11]=2[N:12]=1)[C:16]([NH2:18])=[NH:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178468780HCID 178468780, compound

Product 1

HCID 178512600HCID 178512600, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

A suspension of 2-guanidino-4,5,6,7-tetrahydro-benzothiazole-4-carboxylic acid ethyl ester (5 mmol) and sodium hydroxide (20 mmol) in methanol/water (4:1, 10 ml) is stirred overnight at room temperature. The pH is set at 5 by adding 25% hydrochloric acid and the precipitated product is filtered off. In this way the title compound is obtained (671 mg) in a yield of 56%: tR 0.64 min (LC-1); ESI-MS (+/−): m/z 241.49 [M+H]+/239.37 [M−H]−.

Workup

  1. filtrationthe precipitated product is filtered off

Sources & evidence

ORD record
ord-33413e6dcbc0448487ecea1669d7ccf7
Source dataset
uspto-grants-2010_06
Patent number
US07727979B2

Reaction notes

Loading…