Pyridine → isopropyl 2-chloro-5-[2-chloro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate

HRID 1204336Notes

Reaction equation

HRID 1204336 reaction equation
[CH3:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[Cl:7][c:8]1[c:9]([C:10](=[O:11])[O:12][CH:13]([CH3:14])[CH3:15])[cH:16][c:17](-[n:21]2[c:22](=[O:32])[nH:23][c:24]([C:28]([F:29])([F:30])[F:31])[cH:25][c:26]2=[O:27])[c:18]([F:20])[cH:19]1.[P:33]([Cl:34])([Cl:35])([Cl:36])=[O:37].[cH:1]1[cH:2][cH:3][n:4][cH:5][cH:6]1>>[Cl:7][c:8]1[c:9]([C:10](=[O:11])[O:12][CH:13]([CH3:14])[CH3:15])[cH:16][c:17](-[n:21]2[c:22]([Cl:35])[n:23][c:24]([C:28]([F:29])([F:30])[F:31])[cH:25][c:26]2=[O:27])[c:18]([F:20])[cH:19]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 1140TolueneHCID 24813Phosphorus oxychlorideHCID 19994244isopropyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzoate

Product 1

HCID 19994245isopropyl 2-chloro-5-[2-chloro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate

Sources & evidence

ORD record
ord-7f88666b60ab433cabd6db66cd3a40a2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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