Dichloromethane → Methyl 2-[4-(6-chloro-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate

HRID 1204690Notes

Reaction equation

HRID 1204690 reaction equation
[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[CH3:8][O:9][C:10](=[O:11])[c:12]1[c:13]([C:19]([F:20])([F:21])[F:22])[n:14][c:15]([Cl:18])[n:16][cH:17]1.[Cl:23][c:24]1[n:25][n:26][c:27]([N:32]2[CH2:33][CH:34]([CH3:38])[NH:35][CH2:36][CH2:37]2)[c:28]([CH3:31])[c:29]1[CH3:30].[Cl:39][CH2:40][Cl:41]>>[CH3:8][O:9][C:10](=[O:11])[c:12]1[c:13]([C:19]([F:20])([F:21])[F:22])[n:14][c:15]([N:35]2[CH:34]([CH3:38])[CH2:33][N:32]([c:27]3[n:26][n:25][c:24]([Cl:23])[c:29]([CH3:30])[c:28]3[CH3:31])[CH2:37][CH2:36]2)[n:16][cH:17]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 3696469Methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylateHCID 725393803-Chloro-4,5-dimethyl-6-(3-methylpiperazin-1-yl)pyridazine

Product 1

HCID 72539354Methyl 2-[4-(6-chloro-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate

Sources & evidence

ORD record
ord-e3f58ef1856844be95a2ae022dd01f95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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