Dimethyl Sulfoxide → 3-Chloro-4-[(5-chloropyrimidin-2-yl)oxy]aniline

HRID 1204757Notes

Reaction equation

HRID 1204757 reaction equation
[C:48](=[O:49])([O-:50])[O-:51].[CH3:55][S:56]([CH3:57])=[O:58].[Cl:31][c:32]1[n:33][cH:34][c:35]([Cl:36])[cH:37][n:38]1.[K+:52].[K+:53].[N+:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][c:7]1[C:8]([NH:9][C:10]([NH:11][c:12]1[cH:13][c:14]([Cl:26])[c:15]([O:18][c:19]2[n:20][cH:21][c:22]([Cl:25])[cH:23][n:24]2)[cH:16][cH:17]1)=[O:27])=[O:28])([O-:29])=[O:30].[NH2:39][c:40]1[cH:41][cH:42][c:43]([OH:44])[c:45]([Cl:46])[cH:47]1.[OH2:54]>>[NH2:11][c:12]1[cH:13][c:14]([Cl:26])[c:15]([O:18][c:19]2[n:20][cH:21][c:22]([Cl:25])[cH:23][n:24]2)[cH:16][cH:17]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 775784-Amino-2-chlorophenolHCID 5906412,5-DichloropyrimidineHCID 13771441N-(2-nitrobenzoyl)-N'-[3-chloro-4-(5-chloro-2-pyrimidinyloxy)phenyl]urea

Product 1

HCID 140970913-Chloro-4-[(5-chloropyrimidin-2-yl)oxy]aniline

Sources & evidence

ORD record
ord-75c766c8bd6c4647883e9521510980be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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