Tetrahydrofuran → Ethyl 3-[benzyl(1-phenylethyl)amino]-3-(3-fluoro-4-phenylphenyl)propanoate

HRID 1204930Notes

Reaction equation

HRID 1204930 reaction equation
[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][CH:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH3:16].[CH2:22]([CH3:23])[O:24][C:25]([CH:26]=[CH:27][c:28]1[cH:29][c:30]([F:40])[c:31](-[c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[cH:32][cH:33]1)=[O:41].[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]([CH:9]([c:10]1[cH:11][cH:12][cH:13][cH:14][cH:15]1)[CH3:16])[CH:27]([CH2:26][C:25]([O:24][CH2:22][CH3:23])=[O:41])[c:28]1[cH:29][c:30]([F:40])[c:31](-[c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[cH:32][cH:33]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 519427N-benzyl-1-phenylethylamineHCID 542096623-(2-Fluoro-biphenyl-4-yl)-acrylic acid ethyl esterHCID 178418339Butyllithium

Product 1

HCID 69779747Ethyl 3-[benzyl(1-phenylethyl)amino]-3-(3-fluoro-4-phenylphenyl)propanoate

Sources & evidence

ORD record
ord-676ef533016d4f858db006d226742dc6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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