8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene → 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

HRID 12051Notes

Reaction equation

HRID 12051 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1.[H][H]>[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:17][CH2:16][C:11]3([O:12][CH2:13][CH2:14][O:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 152326828-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-eneHCID 178418361HCID 178418361, compound

Product 1

HCID 128344048-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

8-(4-fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene is hydrogenated using Pd/C with hydrogen. After filtering-off of the catalyst over celite and evaporating-off of the solvent, 8-(4-fluorophenyl)-1,4-dioxaspiro[4.5]decane is obtained in a quantitative yield: tR 3.65 min (LC-1); ESI-MS(+): m/z 237.26 [M+H]+.

Sources & evidence

ORD record
ord-d3ec7ce35c5743429efed8cc6b073b42
Source dataset
uspto-grants-2010_06
Patent number
US07727979B2

Reaction notes

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