Dichloromethane → 2-anilino-6-fluoro-7-[(4-methoxyphenoxy)methyl]-1-phenyl-1,8-naphthyridin-4(1H)-one
Reaction equation
[CH3:28][O:29][c:30]1[cH:31][cH:32][c:33]([OH:36])[cH:34][cH:35]1.[Cl:74][CH2:75][Cl:76].[N:56]([C:57]([N:58]1[CH2:59][CH2:60][CH2:61][CH2:62][CH2:63]1)=[O:64])=[N:65][C:66]([N:67]1[CH2:68][CH2:69][CH2:70][CH2:71][CH2:72]1)=[O:73].[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[n:9](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[c:10]2[n:11][c:12]([CH2:20][OH:21])[c:13]([F:19])[cH:14][c:15]2[c:16](=[O:18])[cH:17]1.[c:37]1([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[cH:51][cH:52][cH:53][cH:54][cH:55]1>>[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[n:9](-[c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[c:10]2[n:11][c:12]([CH2:20][O:21][c:33]3[cH:32][cH:31][c:30]([O:29][CH3:28])[cH:35][cH:34]3)[c:13]([F:19])[cH:14][c:15]2[c:16](=[O:18])[cH:17]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-1c8492b3000d497d9a77850fe95a50d5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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