Hydroxide → 6-tert-butyl-8-fluoro-2-(2-hydroxymethyl-3-{5-[5-(4-hydroxy-4-methyl-piperidine-1-carbonyl)-pyridin-2-ylamino]-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl}-phenyl)-2H-phthalazin-1-one
Reaction equation
[C:1](=[O:2])([CH3:3])[O:4][CH2:5][c:6]1[c:7](-[n:37]2[c:38](=[O:52])[c:39]3[c:40]([F:51])[cH:41][c:42]([C:47]([CH3:48])([CH3:49])[CH3:50])[cH:43][c:44]3[cH:45][n:46]2)[cH:8][cH:9][cH:10][c:11]1-[c:12]1[n:13][n:14]([CH3:36])[c:15](=[O:35])[c:16]([NH:18][c:19]2[n:20][cH:21][c:22]([C:25](=[O:26])[N:27]3[CH2:28][CH2:29][C:30]([CH3:33])([OH:34])[CH2:31][CH2:32]3)[cH:23][cH:24]2)[cH:17]1.[Li+:54].[O:55]1[CH2:56][CH2:57][O:58][CH2:59][CH2:60]1.[OH-:53]>>[OH:4][CH2:5][c:6]1[c:7](-[n:37]2[c:38](=[O:52])[c:39]3[c:40]([F:51])[cH:41][c:42]([C:47]([CH3:48])([CH3:49])[CH3:50])[cH:43][c:44]3[cH:45][n:46]2)[cH:8][cH:9][cH:10][c:11]1-[c:12]1[n:13][n:14]([CH3:36])[c:15](=[O:35])[c:16]([NH:18][c:19]2[n:20][cH:21][c:22]([C:25](=[O:26])[N:27]3[CH2:28][CH2:29][C:30]([CH3:33])([OH:34])[CH2:31][CH2:32]3)[cH:23][cH:24]2)[cH:17]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-956afe71014b4666b36eb0be760656f5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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