Hydrochloric Acid → 2-(3-(4-(7-((2-(Trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

HRID 120588Notes

Reaction equation

HRID 120588 reaction equation
[C:1](#[N:2])[CH2:3][C:4]1([n:15]2[n:16][cH:17][c:18](-[c:20]3[c:21]4[c:22]([n:23][cH:24][n:25]3)[n:26]([CH2:29][O:30][CH2:31][CH2:32][Si:33]([CH3:34])([CH3:35])[CH3:36])[cH:27][cH:28]4)[cH:19]2)[CH2:5][N:6]([C:8]([O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:14])[CH2:7]1.[Cl:44][CH2:45][Cl:46].[ClH:37].[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1>>[C:1](#[N:2])[CH2:3][C:4]1([n:15]2[n:16][cH:17][c:18](-[c:20]3[c:21]4[c:22]([n:23][cH:24][n:25]3)[n:26]([CH2:29][O:30][CH2:31][CH2:32][Si:33]([CH3:34])([CH3:35])[CH3:36])[cH:27][cH:28]4)[cH:19]2)[CH2:5][NH:6][CH2:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 57868843tert-Butyl 3-(cyanomethyl)-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

Product 1

HCID 578688552-(3-(4-(7-((2-(Trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile

Sources & evidence

ORD record
ord-40f2dabcd7ff4ea09d8c2a117b233585
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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