Dichloromethane → N-[4'-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1'-biphenyl-4-yl]methanesulfonamide

HRID 1206081Notes

Reaction equation

HRID 1206081 reaction equation
[CH2:28]([N:29]([CH2:30][CH3:31])[CH2:32][CH3:33])[CH3:34].[CH3:23][S:24](=[O:25])(=[O:26])[Cl:27].[Cl:35][CH2:36][Cl:37].[N:1]12[CH2:2][CH:3]([O:9][c:10]3[cH:11][cH:12][c:13](-[c:16]4[cH:17][cH:18][c:19]([NH2:22])[cH:20][cH:21]4)[cH:14][cH:15]3)[CH:4]([CH2:5][CH2:6]1)[CH2:7][CH2:8]2>>[N:1]12[CH2:2][CH:3]([O:9][c:10]3[cH:11][cH:12][c:13](-[c:16]4[cH:17][cH:18][c:19]([NH:22][S:24]([CH3:23])(=[O:25])=[O:26])[cH:20][cH:21]4)[cH:14][cH:15]3)[CH:4]([CH2:5][CH2:6]1)[CH2:7][CH2:8]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 113469324'-(1-Azabicyclo[2.2.2]oct-3-yloxy)-1,1'-biphenyl-4-amine

Product 1

HCID 11383176N-[4'-(1-azabicyclo[2.2.2]oct-3-yloxy)-1,1'-biphenyl-4-yl]methanesulfonamide

Sources & evidence

ORD record
ord-8513c51ada984b76967b96a0d110e2b7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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