Hydrochloric Acid → 1-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine

HRID 1206131Notes

Reaction equation

HRID 1206131 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][c:16]([C:21]([F:22])([F:23])[F:24])[c:17]([Cl:20])[cH:18][cH:19]2)=[CH:12][CH2:13]1.[CH3:26][OH:27].[ClH:25]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][c:16]([C:21]([F:22])([F:23])[F:24])[c:17]([Cl:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 223452021-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Product 1

HCID 223451981-Benzyl-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidine

Sources & evidence

ORD record
ord-6749261985bf4aa4acc82756cd2edbed
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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