Tetrahydrofuran → (4-Benzyloxy-phenyl)-(6-(4-(1,3-dioxolan-2-yl)-3-methyl-3H-imidazol-2-yl)-quinazolin-4-yl)-amine

HRID 1206179Notes

Reaction equation

HRID 1206179 reaction equation
[Ag-:95]=[O:96].[CH2:12]([Li:13])[CH2:14][CH2:15][CH3:16].[CH2:17]([Sn:18]([Cl:19])([CH2:20][CH2:21][CH2:22][CH3:23])[CH2:24][CH2:25][CH2:26][CH3:27])[CH2:28][CH2:29][CH3:30].[CH2:31]([c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1)[O:38][c:39]1[cH:40][cH:41][c:42]([NH:45][c:46]2[n:47][cH:48][n:49][c:50]3[cH:51][cH:52][c:53]([I:56])[cH:54][c:55]23)[cH:43][cH:44]1.[CH2:57]1[O:58][CH2:59][CH2:60][CH2:61]1.[CH3:1][n:2]1[cH:3][n:4][cH:5][c:6]1[CH:7]1[O:8][CH2:9][CH2:10][O:11]1.[Pd:62]([Cl:63])[Cl:64].[c:65]1([P:66]([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[CH2:73][CH2:74][CH2:75][CH2:76][P:77]([c:78]2[cH:79][cH:80][cH:81][cH:82][cH:83]2)[c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[cH:90][cH:91][cH:92][cH:93][cH:94]1>>[CH3:1][n:2]1[c:3](-[c:53]2[cH:52][cH:51][c:50]3[n:49][cH:48][n:47][c:46]([NH:45][c:42]4[cH:41][cH:40][c:39]([O:38][CH2:31][c:32]5[cH:33][cH:34][cH:35][cH:36][cH:37]5)[cH:44][cH:43]4)[c:55]3[cH:54]2)[n:4][cH:5][c:6]1[CH:7]1[O:8][CH2:9][CH2:10][O:11]1

Participants

9

Reactant 8

HCID 8028TetrahydrofuranHCID 15096Tributyltin ChlorideHCID 24290Palladium ChlorideHCID 821241,4-Bis(diphenylphosphino)butaneHCID 21951950(4-Benzyloxy-phenyl)-(6-iodoquinazolin-4-yl)-amineHCID 226098451-Methyl-5-(1,3-dioxolan-2-yl)-imidazoleHCID 178418339ButyllithiumHCID 178418778HCID 178418778, compound

Product 1

HCID 22609737(4-Benzyloxy-phenyl)-(6-(4-(1,3-dioxolan-2-yl)-3-methyl-3H-imidazol-2-yl)-quinazolin-4-yl)-amine

Sources & evidence

ORD record
ord-3d1fb934d3394b27a86958f3db0d2afd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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