Dichloromethane → (4-Amino-3-fluorophenyl)(piperazin-1-yl)methanone

HRID 1206620Notes

Reaction equation

HRID 1206620 reaction equation
[Cl:31][CH2:32][Cl:33].[NH2:1][c:2]1[c:3]([F:23])[cH:4][c:5]([C:6](=[O:7])[N:8]2[CH2:9][CH2:10][N:11]([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12][CH2:13]2)[cH:21][cH:22]1.[OH:24][C:25]([C:26]([F:27])([F:28])[F:29])=[O:30]>>[NH2:1][c:2]1[c:3]([F:23])[cH:4][c:5]([C:6](=[O:7])[N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:21][cH:22]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58055815Tert-butyl 4-(4-amino-3-fluorobenzoyl)piperazine-1-carboxylate

Product 1

HCID 63187976(4-Amino-3-fluorophenyl)(piperazin-1-yl)methanone

Sources & evidence

ORD record
ord-de05c24b203e4d3fb697db60e0099b1b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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