反应详情

A solution of 43 g (200 mmol) of 4-bromophenylacetic acid and 0.2 g of conc. H2SO4 in 470 ml of ethanol was refluxed for 16 hours. The reaction mixture was cooled to ambient temperature, stirred with 6 g of solid K2CO3 for 30 minutes and then filtered. The filtrate was concentrated in vacuo, diluted with Et2O (200 ml), washed with 10% aqueous NaHCO3 (10 ml) and brine (10 ml), dried over MgSO4 and concentrated in vacuo to give the title compound as a colorless oil.

1. filtrationfiltered
2. concentrationThe filtrate was concentrated in vacuo
3. additiondiluted with Et2O (200 ml)
4. washwashed with 10% aqueous NaHCO3 (10 ml) and brine (10 ml)
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo