Bicarbonate Ion → trans-{4-[(4-Dimethylamino-quinazolin-2-ylamino)-methyl]cyclohexylmethyl}-carbamic acid tert-butyl ester
Reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20]([NH:21][CH2:22][CH:23]1[CH2:24][CH2:25][CH:26]([CH2:29][NH2:30])[CH2:27][CH2:28]1)=[O:31].[CH3:37][CH:38]([OH:39])[CH3:40].[Cl:1][c:2]1[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([N:12]([CH3:13])[CH3:14])[n:11]1.[Na+:36].[O-:32][C:33]([OH:34])=[O:35]>>[c:2]1([NH:30][CH2:29][CH:26]2[CH2:25][CH2:24][CH:23]([CH2:22][NH:21][C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:31])[CH2:28][CH2:27]2)[n:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]2[c:10]([N:12]([CH3:13])[CH3:14])[n:11]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-80ccf1ffd7ec4a6c82f6f857824ffd83
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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