Toluene → Tetrahydropyranyl ether

HRID 1207543Notes

Reaction equation

HRID 1207543 reaction equation
[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[N:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36].[NH2:20][c:21]1[c:22]([CH3:29])[c:23]([CH2:27][OH:28])[cH:24][cH:25][cH:26]1.[O:7]1[CH:8]([O:13][CH:14]2[O:15][CH2:16][CH2:17][CH2:18][CH2:19]2)[CH2:9][CH2:10][CH2:11][CH2:12]1.[cH:1]1[cH:2][n:3][cH:4][cH:5][n:6]1>>[O:7]1[CH:8]([O:13][CH:14]2[O:15][CH2:16][CH2:17][CH2:18][CH2:19]2)[CH2:9][CH2:10][CH2:11][CH2:12]1.[cH:1]1[c:2](-[c:21]2[c:22]([CH3:29])[c:23]([CH2:27][OH:28])[cH:24][cH:25][cH:26]2)[n:3][cH:4][cH:5][n:6]1

Participants

7

Reactant 5

HCID 1140TolueneHCID 9261PyrazineHCID 10906Tert-Butyl nitriteHCID 263182Tetrahydropyranyl etherHCID 577175(3-Amino-2-methylphenyl)methanol

Product 2

HCID 263182Tetrahydropyranyl etherHCID 13243426[2-Methyl-3-(pyrazin-2-yl)phenyl]methanol

Sources & evidence

ORD record
ord-11734df0a558457085110b88b253dbb8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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