Dichloromethane → 5-Chloro-4-(6-cyclopropyl-5-(1,1-difluoroethoxy)pyridin-3-yloxy)-2-fluorobenzoic acid

HRID 1207817Notes

Reaction equation

HRID 1207817 reaction equation
[Cl:1][c:2]1[c:3]([O:16][c:17]2[cH:18][n:19][c:20]([CH:28]3[CH2:29][CH2:30]3)[c:21]([O:23][C:24]([CH3:25])([F:26])[F:27])[cH:22]2)[cH:4][c:5]([F:15])[c:6]([C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[cH:14]1.[Cl:38][CH2:39][Cl:40].[OH:31][C:32]([C:33]([F:34])([F:35])[F:36])=[O:37]>>[Cl:1][c:2]1[c:3]([O:16][c:17]2[cH:18][n:19][c:20]([CH:28]3[CH2:29][CH2:30]3)[c:21]([O:23][C:24]([CH3:25])([F:26])[F:27])[cH:22]2)[cH:4][c:5]([F:15])[c:6]([C:7](=[O:8])[OH:9])[cH:14]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58042461HCID 58042461, compound

Product 1

HCID 580424975-Chloro-4-(6-cyclopropyl-5-(1,1-difluoroethoxy)pyridin-3-yloxy)-2-fluorobenzoic acid

Sources & evidence

ORD record
ord-844761cf64134e12a4ecbc7d40fad1b0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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