Dichloromethane → 2-(2-Chloro-5-(piperidin-4-ylidenemethyl)phenoxy)-5-(trifluoromethyl)pyridine

HRID 120795Notes

Reaction equation

HRID 120795 reaction equation
[Cl:1][c:2]1[c:3]([O:22][c:23]2[n:24][cH:25][c:26]([C:29]([F:30])([F:31])[F:32])[cH:27][cH:28]2)[cH:4][c:5]([CH:6]=[C:7]2[CH2:8][CH2:9][N:10]([C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:11][CH2:12]2)[cH:20][cH:21]1.[Cl:40][CH2:41][Cl:42].[F:33][C:34]([F:35])([F:36])[C:37]([OH:38])=[O:39]>>[Cl:1][c:2]1[c:3]([O:22][c:23]2[n:24][cH:25][c:26]([C:29]([F:30])([F:31])[F:32])[cH:27][cH:28]2)[cH:4][c:5]([CH:6]=[C:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[cH:20][cH:21]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66875839tert-Butyl 4-(4-chloro-3-(5-(trifluoromethyl)pyridin-2-yloxy)benzylidene)piperidine-1-carboxylate

Product 1

HCID 668754652-(2-Chloro-5-(piperidin-4-ylidenemethyl)phenoxy)-5-(trifluoromethyl)pyridine

Sources & evidence

ORD record
ord-aade11ab81784fd8b064332eac601298
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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