Triethylamine → Methyl 3-[2-[[2-[tert-butyl(dimethyl)silyl]oxy-2-[3-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-phenylmethoxyphenyl]ethyl]amino]-2-methylpropyl]benzoate

HRID 1208084Notes

Reaction equation

HRID 1208084 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([CH2:26][O:27][Si:28]([CH3:29])([CH3:30])[C:31]([CH3:32])([CH3:33])[CH3:34])[cH:11][c:12]([CH:15]([CH2:16][Br:17])[O:18][Si:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[CH3:25])[cH:13][cH:14]1.[CH3:50][CH2:51][N:52]([CH2:53][CH3:54])[CH2:55][CH3:56].[NH2:35][C:36]([CH2:37][c:38]1[cH:39][c:40]([C:41](=[O:42])[O:43][CH3:44])[cH:45][cH:46][cH:47]1)([CH3:48])[CH3:49]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([CH2:26][O:27][Si:28]([CH3:29])([CH3:30])[C:31]([CH3:32])([CH3:33])[CH3:34])[cH:11][c:12]([CH:15]([CH2:16][NH:35][C:36]([CH2:37][c:38]2[cH:39][c:40]([C:41](=[O:42])[O:43][CH3:44])[cH:45][cH:46][cH:47]2)([CH3:48])[CH3:49])[O:18][Si:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[CH3:25])[cH:13][cH:14]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 57516949Methyl 3-(2-amino-2-methylpropyl)benzoateHCID 66989869[5-[2-Bromo-1-[tert-butyl(dimethyl)silyl]oxyethyl]-2-phenylmethoxyphenyl]methoxy-tert-butyl-dimethylsilane

Product 1

HCID 123506166Methyl 3-[2-[[2-[tert-butyl(dimethyl)silyl]oxy-2-[3-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-phenylmethoxyphenyl]ethyl]amino]-2-methylpropyl]benzoate

Sources & evidence

ORD record
ord-6c9fb6a51da542efb456957212177f99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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