Methanol → N-[1-amino-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2-chloro-1-methyl-5-(2-methylpyrazol-3-yl)pyrrole-3-carboxamide

HRID 1208316Notes

Reaction equation

HRID 1208316 reaction equation
[CH3:48][OH:49].[Cl:1][c:2]1[n:3]([CH3:40])[c:4](-[c:34]2[cH:35][cH:36][n:37][n:38]2[CH3:39])[cH:5][c:6]1[C:7](=[O:8])[NH:9][CH:10]([CH2:11][N:12]1[C:13](=[O:14])[c:15]2[c:16]([cH:17][cH:18][cH:19][cH:20]2)[C:21]1=[O:22])[CH2:23][c:24]1[c:25]([C:30]([F:31])([F:32])[F:33])[cH:26][cH:27][cH:28][cH:29]1.[NH2:41][NH2:42].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[Cl:1][c:2]1[n:3]([CH3:40])[c:4](-[c:34]2[cH:35][cH:36][n:37][n:38]2[CH3:39])[cH:5][c:6]1[C:7](=[O:8])[NH:9][CH:10]([CH2:11][NH2:12])[CH2:23][c:24]1[c:25]([C:30]([F:31])([F:32])[F:33])[cH:26][cH:27][cH:28][cH:29]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 9321HydrazineHCID 766930062-chloro-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-1-methyl-5-(2-methylpyrazol-3-yl)pyrrole-3-carboxamide

Product 1

HCID 74382828N-[1-amino-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-2-chloro-1-methyl-5-(2-methylpyrazol-3-yl)pyrrole-3-carboxamide

Sources & evidence

ORD record
ord-41dcc043cc9741b7816b10b7cf135c93
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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