Dichloromethane → 5-(4-Amino-3-methoxyphenyl)-4-chloro-7-cyclopentylpyrrolo[2,3-d]pyrimidine

HRID 1208625Notes

Reaction equation

HRID 1208625 reaction equation
[Cl:39][CH2:40][Cl:41].[Cl:8][c:9]1[c:10]2[c:11]([n:12][cH:13][n:14]1)[n:15]([CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1)[cH:16][c:17]2-[c:18]1[cH:19][c:20]([O:32][CH3:33])[c:21]([NH:24][C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[cH:22][cH:23]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[c:10]2[c:11]([n:12][cH:13][n:14]1)[n:15]([CH:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1)[cH:16][c:17]2-[c:18]1[cH:19][c:20]([O:32][CH3:33])[c:21]([NH2:24])[cH:22][cH:23]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 53777291tert-butyl N-[4-(4-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methoxyphenyl]carbamate

Product 1

HCID 541919345-(4-Amino-3-methoxyphenyl)-4-chloro-7-cyclopentylpyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-4e8b992a279e454bbcb904cf37d339f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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