Bromide ion → Tert-butyl 2-[[5-bromo-2-(difluoromethoxy)phenyl]methyl]morpholine-4-carboxylate
Reaction equation
[Br-:58].[C:25]([N:26]1[CH2:27][CH2:28][O:29][CH:30]([CH2:31][c:32]2[cH:33][cH:34][cH:35][c:36]([CH:37]=[CH:38][c:39]3[cH:40][n:41][cH:42][cH:43][cH:44]3)[cH:45]2)[CH2:46]1)([O:47][C:48]([CH3:49])([CH3:50])[CH3:51])=[O:52].[C:3](=[O:4])([O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[N:10]1[CH2:11][CH:12]([CH2:16][c:17]2[c:18]([OH:24])[cH:19][cH:20][c:21]([Br:23])[cH:22]2)[O:13][CH2:14][CH2:15]1.[CH2:59]([N+:60]([CH2:61][CH2:62][CH2:63][CH3:64])([CH2:65][CH2:66][CH2:67][CH3:68])[CH2:69][CH2:70][CH2:71][CH3:72])[CH2:73][CH2:74][CH3:75].[Cl:53][CH:54]([F:55])[F:56].[Na+:2].[O:76]1[CH2:77][CH2:78][O:79][CH2:80][CH2:81]1.[OH-:1].[OH2:57]>>[C:3](=[O:4])([O:5][C:6]([CH3:7])([CH3:8])[CH3:9])[N:10]1[CH2:11][CH:12]([CH2:16][c:17]2[c:18]([O:24][CH:54]([F:55])[F:56])[cH:19][cH:20][c:21]([Br:23])[cH:22]2)[O:13][CH2:14][CH2:15]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-44bc6aa34f5b410aafb22f4be3733e46
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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