Dichloromethane → Trifluoroacetic acid

HRID 1208895Notes

Reaction equation

HRID 1208895 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][cH:8]1)[NH:9][C:10](=[O:42])[C:11]21[CH:12]([c:14]2[cH:15][cH:16][c:17]3[c:18](-[c:23]4[cH:24][cH:25][c:26]([CH:29]5[CH2:30][CH2:31][N:32]([C:35]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:41])[CH2:33][CH2:34]5)[cH:27][cH:28]4)[n:19][nH:20][c:21]3[cH:22]2)[CH2:13]1.[Cl:50][CH2:51][Cl:52].[F:43][C:44]([C:45](=[O:46])[OH:47])([F:48])[F:49]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6]([cH:7][cH:8]1)[NH:9][C:10](=[O:42])[C:11]21[CH:12]([c:14]2[cH:15][cH:16][c:17]3[c:18](-[c:23]4[cH:24][cH:25][c:26]([CH:29]5[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]5)[cH:27][cH:28]4)[n:19][nH:20][c:21]3[cH:22]2)[CH2:13]1.[F:43][C:44]([C:45](=[O:46])[OH:47])([F:48])[F:49]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 123381570tert-butyl 4-[4-[6-(5-methoxy-2-oxospiro[1H-indole-3,2'-cyclopropane]-1'-yl)-1H-indazol-3-yl]phenyl]piperidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 679544225-methoxy-2'-[3-(4-piperidin-4-ylphenyl)-1H-indazol-6-yl]spiro[1H-indole-3,1'-cyclopropane]-2-one

Sources & evidence

ORD record
ord-a5ccab32f76546e99ccbd137281dfb6a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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