Potassium Cation → 3-Bromo-5-(1-methyl-1H-pyrazol-4-yl)pyridine

HRID 1209058Notes

Reaction equation

HRID 1209058 reaction equation
[Br:1][c:2]1[cH:3][n:4][cH:5][c:6]([I:8])[cH:7]1.[CH3:35][O:36][CH2:37][CH2:38][O:39][CH3:40].[CH3:9][n:10]1[n:11][cH:12][c:13]([B:15]2[O:16][C:17]([CH3:18])([CH3:19])[C:20]([CH3:21])([CH3:22])[O:23]2)[cH:14]1.[K+:32].[K+:33].[K+:34].[OH2:24].[OH2:25].[OH2:26].[P:27]([O-:28])([O-:29])([O-:30])=[O:31].[Pd:41]([Cl:42])[Cl:43].[c:44]1([P:45]([c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[cH:58][cH:59][cH:60][cH:61][cH:62]1.[c:63]1([P:64]([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[cH:77][cH:78][cH:79][cH:80][cH:81]1>>[Br:1][c:2]1[cH:3][n:4][cH:5][c:6](-[c:13]2[cH:12][n:11][n:10]([CH3:9])[cH:14]2)[cH:7]1

Participants

9

Reactant 8

HCID 813Potassium Cation3×HCID 962Water3×HCID 1061PhosphateHCID 80711,2-DimethoxyethaneHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 8204093-Bromo-5-iodopyridineHCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 1

HCID 576426663-Bromo-5-(1-methyl-1H-pyrazol-4-yl)pyridine

Sources & evidence

ORD record
ord-55794988d5ad498b88f87f325887568c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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