Water → N-Cyclopropyl-4-methyl-3-(2-(2-morpholinoethyl)thieno[2,3-d]pyrimidin-6-yl)benzamide
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([n:6][c:7]([CH2:10][CH2:11][N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[n:8][cH:9]2)[s:18]1.[CH2:43]1[O:44][CH2:45][CH2:46][O:47][CH2:48]1.[CH3:49][CH2:50][O:51][C:52]([CH3:53])=[O:54].[CH:19]1([NH:22][C:23]([c:24]2[cH:25][c:26]([B:31]3[O:32][C:33]([CH3:34])([CH3:35])[C:36]([CH3:37])([CH3:38])[O:39]3)[c:27]([CH3:30])[cH:28][cH:29]2)=[O:40])[CH2:20][CH2:21]1.[Cs+:42].[F-:41].[OH2:132].[cH:55]1[cH:56][cH:57][c:58]([P:59]([Pd:60]([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([P:80]([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[P:99]([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)([c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)[cH:130][cH:131]1>>[c:2]1(-[c:26]2[cH:25][c:24]([C:23]([NH:22][CH:19]3[CH2:20][CH2:21]3)=[O:40])[cH:29][cH:28][c:27]2[CH3:30])[cH:3][c:4]2[c:5]([n:6][c:7]([CH2:10][CH2:11][N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[n:8][cH:9]2)[s:18]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-12664ca18b104b30aa1f49489324bb97
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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