Trifluoroacetic acid → 2-Piperidin-4-ylethynyl-pyrimidine

HRID 1209807Notes

Reaction equation

HRID 1209807 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([C:14]#[C:15][c:16]2[n:17][cH:18][cH:19][cH:20][n:21]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[F:22][C:23]([F:24])([F:25])[C:26]([OH:27])=[O:28]>>[NH:8]1[CH2:9][CH2:10][CH:11]([C:14]#[C:15][c:16]2[n:17][cH:18][cH:19][cH:20][n:21]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 669398774-Pyrimidin-2-ylethynyl-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 595113452-Piperidin-4-ylethynyl-pyrimidine

Sources & evidence

ORD record
ord-103395be449146bd9663feeb438bce6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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