Triphenylphosphine → 2-[[3-Fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-[(4-fluorophenyl)methyl]-6,6-dimethylmorpholin-3-one

HRID 1209932Notes

Reaction equation

HRID 1209932 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:16])[CH:9]([OH:15])[O:10][C:11]([CH3:13])([CH3:14])[CH2:12]2)[cH:17][cH:18]1.[F:42][c:43]1[cH:44][c:45]([CH:46]=[O:47])[cH:48][cH:49][c:50]1-[n:51]1[cH:52][n:53][c:54]([CH3:56])[cH:55]1.[S:19]([Cl:20])([Cl:21])=[O:22].[c:23]1([P:24]([c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[cH:37][cH:38][cH:39][cH:40][cH:41]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:16])[C:9](=[CH:46][c:45]3[cH:44][c:43]([F:42])[c:50](-[n:51]4[cH:52][n:53][c:54]([CH3:56])[cH:55]4)[cH:49][cH:48]3)[O:10][C:11]([CH3:13])([CH3:14])[CH2:12]2)[cH:17][cH:18]1

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 24386Thionyl ChlorideHCID 689090194-(4-Fluorobenzyl)-2-hydroxy-6,6-dimethylmorpholin-3-oneHCID 707008423-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 690059322-[[3-Fluoro-4-(4-methylimidazol-1-yl)phenyl]methylidene]-4-[(4-fluorophenyl)methyl]-6,6-dimethylmorpholin-3-one

Sources & evidence

ORD record
ord-0578bc90efe043a4b020b311be98359d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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