Dichloromethane → 4-[3-Methanesulfonyl-4-(1-methyl-1H-indole-2-sulfonylamino)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1210075Notes

Reaction equation

HRID 1210075 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][c:16]([S:21](=[O:22])(=[O:23])[CH3:24])[c:17]([NH2:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH3:25][n:26]1[c:27]([S:35](=[O:36])(=[O:37])[Cl:38])[cH:28][c:29]2[cH:30][cH:31][cH:32][cH:33][c:34]12.[CH3:42][N:43]([c:44]1[cH:45][cH:46][n:47][cH:48][cH:49]1)[CH3:50].[Cl:39][CH2:40][Cl:41]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[cH:15][c:16]([S:21](=[O:22])(=[O:23])[CH3:24])[c:17]([NH:20][S:35]([c:27]3[n:26]([CH3:25])[c:34]4[c:29]([cH:28]3)[cH:30][cH:31][cH:32][cH:33]4)(=[O:36])=[O:37])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 229985021-Methylindole-2-sulfonyl chlorideHCID 597599694-(4-Amino-3-methanesulfonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 249670444-[3-Methanesulfonyl-4-(1-methyl-1H-indole-2-sulfonylamino)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-309645d66d7b454aaa8f55a02a1e71f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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