Tetrahydrofuran → (2-Chloro-5-pyridin-4-yl-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone

HRID 1210103Notes

Reaction equation

HRID 1210103 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([NH:8][c:9]2[c:10]([F:16])[cH:11][c:12]([F:15])[cH:13][cH:14]2)[n:6][cH:7]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:17][CH2:18][CH2:19][CH2:20][Li:21].[CH3:42][CH2:43][CH2:44][CH2:45][CH2:46][CH3:47].[Cl:22][c:23]1[c:24]([CH:25]=[O:26])[cH:27][c:28](-[c:31]2[cH:32][cH:33][n:34][cH:35][cH:36]2)[cH:29][cH:30]1>>[c:2]1([C:25]([c:24]2[c:23]([Cl:22])[cH:30][cH:29][c:28](-[c:31]3[cH:32][cH:33][n:34][cH:35][cH:36]3)[cH:27]2)=[O:26])[cH:3][cH:4][c:5]([NH:8][c:9]2[c:10]([F:16])[cH:11][c:12]([F:15])[cH:13][cH:14]2)[n:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8058HexaneHCID 22349574(5-Bromo-pyridin-2-yl)-(2,4-difluoro-phenyl)-amineHCID 223495862-Chloro-5-(pyridin-4-yl)benzaldehydeHCID 178418339Butyllithium

Product 1

HCID 10295763(2-Chloro-5-pyridin-4-yl-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone

Sources & evidence

ORD record
ord-e1fc0789e611427f9b741d9a8a4f760b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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