Dichloromethane → Trifluoroacetate

HRID 1210145Notes

Reaction equation

HRID 1210145 reaction equation
[Cl:34][CH2:35][Cl:36].[F:27][C:28]([C:29](=[O:30])[OH:31])([F:32])[F:33].[c:1]1([CH:7]2[CH:8]([C:10](=[O:11])[N:12]3[CH2:13][CH2:14][CH:15]([CH2:18][NH:19][C:20](=[O:21])[O:22][C:23]([CH3:24])([CH3:25])[CH3:26])[CH2:16][CH2:17]3)[CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[F:27][C:28]([C:29](=[O:30])[O-:31])([F:32])[F:33].[c:1]1([CH:7]2[CH:8]([C:10](=[O:11])[N:12]3[CH2:13][CH2:14][CH:15]([CH2:18][NH2:19])[CH2:16][CH2:17]3)[CH2:9]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 23577319[1-(2-Phenyl-cyclopropanecarbonyl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester

Product 2

HCID 84468TrifluoroacetateHCID 22135732[4-(Aminomethyl)piperidin-1-yl]-(2-phenylcyclopropyl)methanone

Sources & evidence

ORD record
ord-706df67ebafe4c0baa1d433b2e996b37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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