3,5-Dichlorobenzoic acid → tert-Butyl 4-[(3,5-dichlorobenzamido)methyl]-4-fluoropiperidine-1-carboxylate
Reaction equation
[CH:22]([N:23]([CH:24]([CH3:25])[CH3:26])[CH2:27][CH3:28])([CH3:29])[CH3:30].[Cl:11][c:12]1[cH:13][c:14]([C:15](=[O:16])[OH:17])[cH:18][c:19]([Cl:21])[cH:20]1.[Cl:47][CH2:48][Cl:49].[NH2:31][CH2:32][C:33]1([F:46])[CH2:34][CH2:35][N:36]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:37][CH2:38]1.[OH:1][n:2]1[c:3]2[cH:4][cH:5][cH:6][cH:7][c:8]2[n:9][n:10]1>>[Cl:11][c:12]1[cH:13][c:14]([C:15](=[O:17])[NH:31][CH2:32][C:33]2([F:46])[CH2:34][CH2:35][N:36]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:37][CH2:38]2)[cH:18][c:19]([Cl:21])[cH:20]1Participants
6
Sources & evidence
- ORD record
- ord-a431cce13adc49d9a97c1404230dc073
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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