Dichloromethane → 4-(Azetidine-1-carbonyl)piperidine

HRID 1210754Notes

Reaction equation

HRID 1210754 reaction equation
[CH2:27]([Cl:28])[Cl:29].[N:1]1([C:5](=[O:6])[CH:7]2[CH2:8][CH2:9][N:10]([C:13]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[CH2:11][CH2:12]2)[CH2:2][CH2:3][CH2:4]1.[OH:20][C:21]([C:22]([F:23])([F:24])[F:25])=[O:26]>>[N:1]1([C:5](=[O:6])[CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 23658779tert-Butyl 4-[(azetidin-1-yl)carbonyl]piperidine-1-carboxylate

Product 1

HCID 236587804-(Azetidine-1-carbonyl)piperidine

Sources & evidence

ORD record
ord-a6ed5dc52f7a4942866b4520770dc694
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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