Hydrochloric Acid → HCID 22063466, compound

HRID 12110Notes

Reaction equation

HRID 12110 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:13]C=O)([CH3:12])[CH3:11])[CH:5]=[C:6]([CH3:8])[CH:7]=1.Cl>>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH2:13])([CH3:11])[CH3:12])[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86078614HCID 86078614, compound

Product 1

HCID 22063466HCID 22063466, compound

Procedure

By reacting 6.00 g (34 mmol) of 1-(3,5-dimethylphenyl)-2-methylpropanol-2-ol and 2.00 g (41 mmol) of sodium cyanide in a Ritter reaction, 2.40 g of 2-(3,5-dimethylphenyl)-1,1-dimethylethylformamide (35% yield) is obtained. To liberate the amine, the formamide (2.40 g, 11.7 mmol) is treated with hydrochloric acid. The method and working up are analogous to the method for Example 10(c). Oil. Yield: 1.70 g (82%); mass spectroscopy: [M+H]+=178.

Sources & evidence

ORD record
ord-cee3b1257d7f45e59f2a7498651adc5e
Source dataset
uspto-grants-2010_06
Patent number
US07727984B2

Reaction notes

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