Methanol → N-[1-amino-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide

HRID 121151Notes

Reaction equation

[CH3:48][OH:49].[Cl:1][c:2]1[c:3](-[c:34]2[c:35]([Cl:40])[cH:36][n:37][n:38]2[CH3:39])[cH:4][c:5]([C:7](=[O:8])[NH:9][CH:10]([CH2:11][N:12]2[C:13](=[O:14])[c:15]3[c:16]([cH:17][cH:18][cH:19][cH:20]3)[C:21]2=[O:22])[CH2:23][c:24]2[c:25]([C:30]([F:31])([F:32])[F:33])[cH:26][cH:27][cH:28][cH:29]2)[o:6]1.[NH2:41][NH2:42].[O:43]1[CH2:44][CH2:45][CH2:46][CH2:47]1>>[Cl:1][c:2]1[c:3](-[c:34]2[c:35]([Cl:40])[cH:36][n:37][n:38]2[CH3:39])[cH:4][c:5]([C:7](=[O:8])[NH:9][CH:10]([CH2:11][NH2:12])[CH2:23][c:24]2[c:25]([C:30]([F:31])([F:32])[F:33])[cH:26][cH:27][cH:28][cH:29]2)[o:6]1

Participants

Reactant 4

HCID 887Methanol

HCID 8028Tetrahydrofuran

HCID 9321Hydrazine

HCID 765764795-chloro-4-(4-chloro-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]furan-2-carboxamide

Product 1

HCID 76576377N-[1-amino-3-[2-(trifluoromethyl)phenyl]propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide

Sources & evidence

ORD record: ord-cc435a9039a140ebaeef176b4f1d988e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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