反应详情

4.00 g (18.5 mmol) of N-[2-(3,4-difluorophenyl)-1,1-dimethylethyl]formamide is dissolved in ethanol, combined with concentrated hydrochloric acid, and refluxed overnight. The reaction solution is poured onto ice water, made alkaline with sodium hydroxide, and extracted with tert-butylmethyl ether. The organic phases are washed with water, dried with sodium sulfate, and evaporated down. Yellow oil. Yield: 3.2 g (92%); mass spectrometry: [M+H]+=186.

1. temperaturerefluxed overnight
2. additionThe reaction solution is poured onto ice water
3. extractionextracted with tert-butylmethyl ether
4. washThe organic phases are washed with water
5. dry with materialdried with sodium sulfate
6. customevaporated down