Tetrahydrofuran → Propan-2-yl 4-[[7-[2-fluoro-4-(1,3-thiazol-2-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

HRID 1212156Notes

Reaction equation

HRID 1212156 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:30])[c:5]([N:8]2[CH2:9][CH2:10][c:11]3[c:12]2[n:13][cH:14][n:15][c:16]3[O:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][CH:27]([CH3:28])[CH3:29])[CH2:22][CH2:23]2)[cH:6][cH:7]1.[CH2:31]([Sn:32]([CH2:33][CH2:34][CH2:35][CH3:41])([c:36]1[s:37][cH:38][cH:39][n:40]1)[CH2:42][CH2:43][CH2:44][CH3:45])[CH2:46][CH2:47][CH3:48].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1>>[c:2]1(-[c:36]2[s:37][cH:38][cH:39][n:40]2)[cH:3][c:4]([F:30])[c:5]([N:8]2[CH2:9][CH2:10][c:11]3[c:12]2[n:13][cH:14][n:15][c:16]3[O:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][CH:27]([CH3:28])[CH3:29])[CH2:22][CH2:23]2)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 69063759HCID 69063759, compound

Product 1

HCID 58016984Propan-2-yl 4-[[7-[2-fluoro-4-(1,3-thiazol-2-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-352cd24765e347ceb446c217122648ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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