Potassium Cation → 5-(4-Methyl-thiazol-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

HRID 1212382Notes

Reaction equation

HRID 1212382 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([B:17]3[O:18][C:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[O:25]3)[cH:14][c:15]2[CH2:16]1.[C:26](=[O:27])([O-:28])[O-:29].[I:32][c:33]1[s:34][cH:35][c:36]([CH3:38])[n:37]1.[K+:30].[K+:31].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13](-[c:33]3[s:34][cH:35][c:36]([CH3:38])[n:37]3)[cH:14][c:15]2[CH2:16]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 16102684Tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)isoindoline-2-carboxylateHCID 231545942-Iodo-4-methyl-1,3-thiazole

Product 1

HCID 577537115-(4-Methyl-thiazol-2-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-03ad20eb99b843d687015c1833eaf933
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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