Dichloromethane → N-[5-(3,5-Dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazol-3-yl]-1-(4-fluorophenyl)-methanesulfonamide

HRID 1213064Notes

Reaction equation

HRID 1213064 reaction equation
[C:1](#[N:2])[C:3]1=[C:4]([CH3:40])[NH:5][C:6]([CH3:39])=[C:7]([C:37]#[N:38])[CH:8]1[c:9]1[cH:10][c:11]2[c:12]([NH:25][S:26](=[O:27])(=[O:28])[CH2:29][c:30]3[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]3)[n:13][n:14]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[c:15]2[cH:16][cH:17]1.[Cl:48][CH2:49][Cl:50].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[C:1](#[N:2])[C:3]1=[C:4]([CH3:40])[NH:5][C:6]([CH3:39])=[C:7]([C:37]#[N:38])[CH:8]1[c:9]1[cH:10][c:11]2[c:12]([NH:25][S:26](=[O:27])(=[O:28])[CH2:29][c:30]3[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]3)[n:13][nH:14][c:15]2[cH:16][cH:17]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67023851tert-Butyl 5-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-3-{[(4-fluorobenzyl)sulfonyl]-amino}-1H-indazole-1-carboxylate

Product 1

HCID 44547841N-[5-(3,5-Dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazol-3-yl]-1-(4-fluorophenyl)-methanesulfonamide

Sources & evidence

ORD record
ord-50e7238053ab4c769f8c6e75c243f20e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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