Hydrochloric Acid → 1-Cyclopropyl-7-fluoro-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

HRID 1213176Notes

Reaction equation

HRID 1213176 reaction equation
[CH3:26][NH:27][CH:28]1[CH2:29][NH:30][CH2:31]1.[CH:1]1([n:4]2[cH:5][c:6]([C:21](=[O:22])[OH:23])[c:7](=[O:20])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[cH:14][c:15]([F:19])[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1.[ClH:24].[ClH:25]>>[CH:1]1([n:4]2[cH:5][c:6]([C:21](=[O:22])[OH:23])[c:7](=[O:20])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[cH:14][c:15]([N:30]2[CH2:29][CH:28]([NH:27][CH3:26])[CH2:31]2)[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 10086969N-methylazetidin-3-amineHCID 148533411-Cyclopropyl-7,8-difluoro-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

Product 1

HCID 194236841-Cyclopropyl-7-fluoro-8-(3-methylamino-1-azetidinyl)-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-c462e33ba1354f4e8561f2f5a39ceac7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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