Methyl 3-mercaptopropionate → Methyl 3-[[6-[[3-(1,4-dioxaspiro[4.5]decan-3-yl)-1,2,4-thiadiazol-5-yl]amino]-5-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]sulfanyl]propanoate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:24][c:25]2[c:26]([CH3:31])[n:27][cH:28][cH:29][cH:30]2)[c:5]([NH:8][c:9]2[n:10][c:11]([CH:14]3[O:15][C:16]4([O:17][CH2:18]3)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]4)[n:12][s:13]2)[n:6][cH:7]1.[CH:39]([N:40]([CH2:41][CH3:42])[CH:43]([CH3:44])[CH3:45])([CH3:46])[CH3:47].[O:50]=[C:51]([CH:52]=[CH:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1)[CH:60]=[CH:61][c:62]1[cH:63][cH:64][cH:65][cH:66][cH:67]1.[O:68]=[C:69]([CH:70]=[CH:71][c:72]1[cH:73][cH:74][cH:75][cH:76][cH:77]1)[CH:78]=[CH:79][c:80]1[cH:81][cH:82][cH:83][cH:84][cH:85]1.[O:86]=[C:87]([CH:88]=[CH:89][c:90]1[cH:91][cH:92][cH:93][cH:94][cH:95]1)[CH:96]=[CH:97][c:98]1[cH:99][cH:100][cH:101][cH:102][cH:103]1.[Pd:48].[Pd:49].[SH:32][CH2:33][CH2:34][C:35](=[O:36])[O:37][CH3:38]>>[c:2]1([S:32][CH2:33][CH2:34][C:35](=[O:36])[O:37][CH3:38])[cH:3][c:4]([O:24][c:25]2[c:26]([CH3:31])[n:27][cH:28][cH:29][cH:30]2)[c:5]([NH:8][c:9]2[n:10][c:11]([CH:14]3[O:15][C:16]4([O:17][CH2:18]3)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]4)[n:12][s:13]2)[n:6][cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-9c5c926cad014a6cb6ba2b50fac9e4be
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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