[2-(2-{4-[3-(2-Hydroxy-5-methyl-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-piperidin-1-yl)-2-oxo-1-phenyl-ethyl]-carbamic acid tert-butyl ester → [2-(3-{4-[3-(5-Chloro-2-hydroxy-phenyl)-1-methyl-1H-pyrazol-4-ylethynyl]-phenylcarbamoyl}-morpholin-4-yl)-2-oxo-1-phenyl-ethyl]-carbamic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]([C:9](=[O:10])[N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH:16]1[C:17](=[O:18])[NH:19][c:20]1[cH:21][cH:22][c:23]([C:24]#[C:25][c:26]2[c:27](-[c:28]3[cH:29][c:30]([CH3:31])[cH:32][cH:33][c:34]3[OH:35])[n:36][n:37]([CH3:38])[cH:39]2)[cH:40][cH:41]1)[c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)=[O:48].[Cl:49][c:50]1[cH:51][cH:52][c:53]([OH:79])[c:54](-[c:56]2[n:57][n:58]([CH3:78])[cH:59][c:60]2[C:61]#[C:62][c:63]2[cH:64][cH:65][c:66]([NH:69][C:70](=[O:71])[CH:72]3[CH2:73][O:74][CH2:75][CH2:76][NH:77]3)[cH:67][cH:68]2)[cH:55]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][CH:8]([C:9](=[O:10])[N:77]1[CH:72]([C:70]([NH:69][c:66]2[cH:65][cH:64][c:63]([C:62]#[C:61][c:60]3[c:56](-[c:54]4[c:53]([OH:79])[cH:52][cH:51][c:50]([Cl:49])[cH:55]4)[n:57][n:58]([CH3:78])[cH:59]3)[cH:68][cH:67]2)=[O:71])[CH2:73][O:74][CH2:75][CH2:76]1)[c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)=[O:48]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-965030287f4f4b00922bf9839e665f43
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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