Dichloromethane → 6-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
Reaction equation
[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[N:27]1[CH2:28][c:29]2[cH:30][cH:31][c:32]([NH2:37])[cH:33][c:34]2[CH2:35][CH2:36]1.[CH2:47]([Cl:48])[Cl:49].[CH3:38][N:39]([c:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1)[CH3:46].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[c:10]([C:15](=[O:16])[OH:17])[cH:11][cH:12][cH:13][cH:14]2)[cH:7][cH:8]1)([F:18])[F:19]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[c:10]([C:15](=[O:17])[NH:37][c:32]3[cH:31][cH:30][c:29]4[c:34]([cH:33]3)[CH2:35][CH2:36][N:27]([C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:26])[CH2:28]4)[cH:11][cH:12][cH:13][cH:14]2)[cH:7][cH:8]1)([F:18])[F:19]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-90843e85310f420897e9af880010f0d0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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