Tetrahydrofuran → 2-{difluoro[4-(5-fluoropyridin-2-yl)phenyl]acetyl}-4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
Reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:6][C:7]([CH2:8][c:9]1[n:10][cH:11][n:12]([S:14](=[O:15])(=[O:16])[N:17]([CH3:18])[CH3:19])[cH:13]1)([CH3:20])[CH3:21].[F:22][C:23]([C:24](=[O:25])[N:26]([O:27][CH3:28])[CH3:29])([c:30]1[cH:31][cH:32][c:33](-[c:36]2[n:37][cH:38][c:39]([F:42])[cH:40][cH:41]2)[cH:34][cH:35]1)[F:43].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[CH3:6][C:7]([CH2:8][c:9]1[n:10][c:11]([C:24]([C:23]([F:22])([c:30]2[cH:31][cH:32][c:33](-[c:36]3[n:37][cH:38][c:39]([F:42])[cH:40][cH:41]3)[cH:34][cH:35]2)[F:43])=[O:25])[n:12]([S:14](=[O:15])(=[O:16])[N:17]([CH3:18])[CH3:19])[cH:13]1)([CH3:20])[CH3:21]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-dbebf12f945f49508da104a7bdaa6766
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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