Dimethylformamide → 2-({3-[1-(cyclohexylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide

HRID 1214328Notes

Reaction equation

HRID 1214328 reaction equation
[Br:39][CH2:40][C:41](=[O:42])[NH2:43].[C:33](=[O:34])([O-:35])[O-:36].[CH3:44][N:45]([CH3:46])[CH:47]=[O:48].[CH:1]1([NH:7][n:8]2[c:9](=[O:32])[c:10]([C:19]3=[N:20][S:21](=[O:30])(=[O:31])[c:22]4[c:23]([cH:25][cH:26][c:27]([OH:29])[cH:28]4)[NH:24]3)[c:11]([OH:18])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]23)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[Cs+:37].[Cs+:38]>>[CH:1]1([NH:7][n:8]2[c:9](=[O:32])[c:10]([C:19]3=[N:20][S:21](=[O:30])(=[O:31])[c:22]4[c:23]([cH:25][cH:26][c:27]([O:29][CH2:40][C:41](=[O:42])[NH2:43])[cH:28]4)[NH:24]3)[c:11]([OH:18])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]23)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 696322-BromoacetamideHCID 104967Cesium cation2×HCID 1363742711-(cyclohexylamino)-4-hydroxy-3-(7-hydroxy-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)quinolin-2(1H)-one

Product 1

HCID 1363737832-({3-[1-(cyclohexylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide

Sources & evidence

ORD record
ord-a988938d9de045369258bb3889d14038
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

Loading…