Dichloromethane → 3-[2-(3-Aminopyrrolidine-1-carbonyl)-thiazolo[4,5-h]quinazolin-8-ylamino]-benzenesulfonamide

HRID 1214707Notes

Reaction equation

HRID 1214707 reaction equation
[C:8]([O:9][C:10](=[O:11])[NH:14][CH:15]1[CH2:16][N:17]([C:20](=[O:21])[c:22]2[s:23][c:24]3[c:25]([cH:26][cH:27][c:28]4[cH:29][n:30][c:31]([NH:34][c:35]5[cH:36][c:37]([S:41]([NH2:42])(=[O:43])=[O:44])[cH:38][cH:39][cH:40]5)[n:32][c:33]34)[n:45]2)[CH2:18][CH2:19]1)([CH3:12])([CH3:13])[CH3:46].[Cl:47][CH2:48][Cl:49].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[NH2:14][CH:15]1[CH2:16][N:17]([C:20](=[O:21])[c:22]2[s:23][c:24]3[c:25]([cH:26][cH:27][c:28]4[cH:29][n:30][c:31]([NH:34][c:35]5[cH:36][c:37]([S:41]([NH2:42])(=[O:43])=[O:44])[cH:38][cH:39][cH:40]5)[n:32][c:33]34)[n:45]2)[CH2:18][CH2:19]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59262801{1-[8-(3-Sulfamoyl-phenylamino)-thiazolo[4,5-h]quinazoline-2-carbonyl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester

Product 1

HCID 592629513-[2-(3-Aminopyrrolidine-1-carbonyl)-thiazolo[4,5-h]quinazolin-8-ylamino]-benzenesulfonamide

Sources & evidence

ORD record
ord-2d88adcc678f463db5f3ea97e9a040ff
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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