Dimethyl Sulfoxide → Tert-butyl 4,4-difluoro-2-formylpyrrolidine-1-carboxylate

HRID 1214790Notes

Reaction equation

HRID 1214790 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:15][OH:16])[CH2:10][C:11]([F:13])([F:14])[CH2:12]1.[CH3:17][CH2:18][N:19]([CH2:20][CH3:21])[CH2:22][CH3:23].[CH3:24][S:25]([CH3:26])=[O:27].[Cl:28][CH2:29][Cl:30]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:15]=[O:16])[CH2:10][C:11]([F:13])([F:14])[CH2:12]1

Participants

5

Reactant 4

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 22001352Tert-butyl 4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Product 1

HCID 23511694Tert-butyl 4,4-difluoro-2-formylpyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-ebc9f451774e4aba94c4422f05c3ff67
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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